Python Basics
Remove mapping bias
In the research of alleles, one of the important steps is to remove the alignment bias. As we all know, human beings are diploid organisms, there will be a pair of alleles at the same position on the chromosome, which is generally homozygous (homozygous); sometimes one of the alleles is mutated (it can be understood as a SNP, oligonucleotide polymorphism) ), will become heterozygous (heterozygous) state.image.pngIf a person is heterozygous at a certain locus, such as AG (A is consistent with the